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Receptory aktywowane przez proliferatory peroksysomów (PPAR) należą do rodziny receptorów jądrowych. Dotychczas scharakteryzowano ich trzy izoformy: alfa, beta i gamma, które jako ligando-zależne czynniki transkrypcyjne zaangażowane są w regulację różnych procesów fizjologicznych w organizmie. Ich podstawową funkcją jest udział w metabolizmie lipidów i glukozy. PPAR uczestniczą również w reakcji zapalnej...
Metalloproteinases (MMP) are proteolytic enzymes whose activity is determined by the presence of zinc ion in the active site and are a widely distributed family of protease to ensure the preservation of homeostasis in animals. In human body they also play many important functions participating in the process of embryogenesis as well as in the formation of blood cells or bone formation. The main role,...
Increased generation of reactive oxygen species (ROS) lies at the background of many diseases, including cancer. Numerous experimental data show that ROS play direct and indirect role in induction and promotion of cancer. Antioxidants, such as glutathione, bilirubin, urate, carotenoids, ascorbate, tocopherols, retinol, belong to nonenzymatic protective mechanisms against ROS antioxidents. A number...
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