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Ubiquitin-proteasome system is emerging as an immensely important enzymatic pathway playing central roles in protein degradation and signaling in numerous human diseases. Building on the prolific success of targeting the ubiquitin-proteasome system in cancer, the broader scientific community is currently seeking to elucidate the potential roles of this enzymatic system in other diseases such as autoimmune...
The interaction of coagulation factors with the perivascular environment affects the development of disease in ways that extend beyond their traditional roles in the acute hemostatic cascade. Key molecular players of the coagulation cascade like tissue factor, thrombin, and fibrinogen are epidemiologically and mechanistically linked with diseases with an inflammatory component. Moreover, the identification...
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