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In neurons, the process of axonal transport helps maintain health and homeostasis for normal neuronal functions. Protein products, synthesized in the cell body and organelles such as mitochondria, are transported via molecular “motors” to the synapse for incorporation into membranes or cytoskeletal architecture, release into the synaptic cleft, or use in synaptic functioning. Retrograde transport...
Neurofilaments (NFs) are neuronal intermediate filaments assembled mainly from three subunit proteins, NF-L, NF-M and NF-H. NFs are the major cytoskeletal element of axons, particularly large myelinated axons. Accumulation of NFs in the cell body or proximal axons is a hallmark of motor neuron diseases, of which aging is a risk factor. It is not known whether the accumulation of NFs is the primary...
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