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Background This study aims to assess the clinical and physiological effects of Roux-en-Y gastric bypass (RYGBP) on type 2 diabetes associated with mild obesity (body mass index [BMI] 30–34.9 kg/m2) over 24 months postsurgery. Methods In this prospective trial, 36 mildly obese subjects (19 males) with type 2 diabetes using oral antidiabetic drugs with (n = 24) or without insulin (n = 12) underwent...
Résumé L’épidémie d’obésité se développe dans le monde entier et a désormais gagné la France. Parallèlement, le diabète de type 2 (DT2) atteint 4 % de la population dont 80 % sont obèses. Dans ce contexte, la chirurgie bariatrique a fait la preuve de son efficacité entrainant la guérison des maladies associées, en particulier du DT2. D’après la Haute Autorité de Santé (HAS), cette chirurgie est soumise...
By itself, glucagon-like peptide-1(GLP-1) appears to be an excellent drug for appetite control and the treatment of obesity. Unfortunately, few enzymes, such as IV dipeptidyl peptidase and renal excretin, degrade and render GLP-1 inactive within minutes. A receptor agonist, exendin-4, with a longer biological half-life than GLP-1, has been tried. Subcutaneous injection of exendin-4 or continuous IV...
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