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Conjugated eicosapentaenoic acid (cEPA) selectively inhibited the activities of mammalian DNA polymerases (pols) and human DNA topoisomerases (topos) [Yonezawa Y, Tsuzuki T, Eitsuka T, Miyazawa T, Hada T, Uryu K, et al. Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II. Arch Biochem Biophys 2005;435:197–206]. In this report, we investigated the inhibitory effect...
Dehydroaltenusin was found to be an inhibitor of mammalian DNA polymerase α (pol. α) in vitro, but did not influence the activities of the other replicative DNA polymerases including even other vertebrate pol. α. In this study, we purified or synthesized various slightly modified derivatives of dehydroaltenusin, and using them, investigated the relationship between the chemical structure and the inhibitory...
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