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This paper used the finite element method to analyze the cerebrovascular bifurcation. By comparison, we constructed two intracranial artery bifurcation vessel models with different angles, and considered different model how to influence vascular blood flow based on the basic principles of hemodynamics. Through experiment, we mainly computed the value of blood velocity and wall pressure, and compared...
This work aims to show on a very concrete example that simulations (In-Silico experiments) can help drug discovery process and therapeutic strategies search. Such an approach must be based, to reflect the complexity of physiological systems, on a modeling methodology taking into account several organization levels and time scales, and focused on physiological functions and their interactions. First,...
We developed a physiologically-based model to quantify cardiovascular control during the Valsalva maneuver. Our mathematical model analyses measured heart rate and peripheral vascular resistance dynamics and takes into account the hemodynamic changes occurring during intra-thoracic and intra-abdominal pressure elevation. Furthermore the model includes simulation of the baroreflex and could fit 44...
In this study, thirty methyl methacrylate casts were used to map the pulmonary artery of normal lambs, ranging in age from two to 100 days. The three-dimensional (3-D) computer tomography (CT) images of these casts were processed to extract the representative geometric parameters of the pulmonary artery. The growth pattern of the geometry of the normal pulmonary artery was analyzed by relating these...
Summary form only given. An attempt has been made to construct a mathematical model of the cardiovascular system which will allow one to simulate the effects of changes in one or more hemodynamic parameters on myocardial oxygen supply and demand. The model used is a combination of several models which have been reported in the literature, along with the authors' own modifications.<<ETX>>
The authors examined the dynamics of an intra aortic balloon (IAB) in the aorta and its effect on the hemodynamic response of the cardiovascular system. A mathematical model was developed and in vivo animal experiments were performed. The model describes the balloon inflation and deflation as an aortic-pressure-dependent wavefront. To validate the model, X-ray images and hemodynamic waveforms were...
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