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Deep brain stimulation (DBS) therapy relies on electrical stimulation of neuronal elements in small brain targets. However, the lack of fine spatial control over field distributions in current systems implies that stimulation easily spreads into adjacent structures that may induce adverse side-effects. This study investigates DBS field steering using a novel DBS lead design carrying a high-resolution...
In this study, fixed potential amperometry was used to examine several pathways by which deep brain stimulation (DBS) of the subthalamic nucleus (STN) or dopamine axons within the dorsal forebrain bundle (DFB) release striatal dopamine, thus potentially providing therapeutic benefits for Parkinson's disease patients. In urethane anesthetized mice, electrical stimulations (20 monophasic pulses at 50...
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