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Accumulation of advanced glycation endproducts (AGE) in the brain is a feature of ageing and degeneration, especially in Alzheimer's disease (AD). Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (ss-amyloid and MAP-τ), oxidative stress and neuronal cell death. Oxidative stress and AGEs initiate a positive feedback loop,...
β-Amyloid peptide has been reported to be toxic to neurons in vitro and in vivo. The fragment of the β1–42 peptide believed to be responsible for this toxicity consists of amino acids 25 to 35. β-Amyloid protein, heparan sulfate (HS) glycosaminoglycan (GAG), and proteoglycan (PG) are all localized throughout the senile plauqes found in Alzheimer's disease. Chondroitin sulfate (CS) and dermatan sulfate...
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