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Some neuropathological changes characteristic of aging and Alzheimer's disease (AD) in humans are present also in senescent non-human primates. The human apoE4 allele is associated with an increased risk of developing late-onset familial and sporadic AD. We found that rhesus monkeys and three sub-species of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158...
We have found an APOE 4 allelic frequency of 0.289 (95% CI 0.195-0.383) in Spanish AD patients (n = 88; average age = 71.2 ± 9.37) and of 0.061 (95% CI 0.023-0.099) in age-matched controls (n = 147; average age = 71.5 ± 10.29). Remarkably no ApoE44 subjects were observed in any of the age-matched control groups compared to a total of 22 AD patients with the ApoE44 phenotype. The combined odds...
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