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Objective
To determine the rates of brain atrophy progression in vivo in patients with multiple system atrophy (MSA).
Background
Surrogate biomarkers of disease progression are a major unmet need in MSA. Small‐scale longitudinal studies in patients with MSA using magnetic resonance imaging (MRI) to assess progression of brain atrophy have produced inconsistent results. In recent years, novel MRI...
Background and Purpose
In multiple sclerosis (MS), brain atrophy measurements have emerged as an important biomarker reflecting neurodegeneration and disability progression. However, due to several potential confounders, investigation of brain atrophy in clinical routine and even in controlled clinical studies can be challenging. The aim of this study was to investigate the short‐term dynamics of...