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Protein turnover, orchestrated by a large array of proteases, protein complexes, and organelles consumes one-fifth of the human energy. In many diseases this homeostasis is lost resulting in loss of tissue function. One such group of diseases are the fibrotic disorders in which there is progressive fibroproliferation and extracellular matrix deposition. The causes of these diseases are sometimes identified,...
Recently there has been a paradigm shift in what is considered to be the therapeutic promise of mesenchymal stem cells (MSCs) in diseases of vital organs. Originally, research focused on MSCs as a source of regenerative cells by differentiation of transplanted cells into lost cell types. It is now clear that trophic modulation of inflammation, cell death, fibrosis, and tissue repair are the main mechanisms...
Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn’s disease, diabetes, and cancer. Lately, this concept has further been substantiated by the finding that...
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