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The hallmark of rheumatoid arthritis (RA) is chronic synovial inflammation resulting in progressive joint damage. Cytokines are key mediators of inflammation and can be found in abundance both in the joint and blood of patients with active disease. They are responsible not only for the destructive synovitis but also for some of the systemic features. Research over the last 2 decades has highlighted...
This review briefly summarizes recent information on the role of cytokines in pathophysiologic events in human rheumatic and inflammatory diseases. The major focus is on rheumatoid arthritis and on the role of interleukin (IL)-1 and tumor necrosis factor-α (TNF) in mediating synovial events of inflammation and tissue destruction. The results of clinical trials with therapeutic agents designed to inhibit...
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