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Anxiety and depression are the most prevalent of the psychiatric disorders. The average age of onset of these disorders is in adolescence, and stressful experiences are recognized as an important pathway to such dysfunction. Until recently, however, most animal models of these disorders involved adult males. We provide a brief overview of anxiety and depression and the extent to which adolescent rodents...
Child abuse is the most significant environmental risk factor for the development of mood disorders, which occur twice as frequently in women as in men. To determine whether juvenile social subjugation (JSS) of rats induces mood disorder-like symptoms, we exposed 28day-old male and female rats to daily aggressive acts from aggressive male residents. Each rat received pins, kicks, and dominance postures...
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