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The established or potentially toxic agents implicated in the nigral cell death in Parkinson's disease, dopamine, 1-methyl-4-phenylpyridinium (MPP + ), iron, and manganese, were examined as to their effects on the viability of cells overexpressing α-synuclein. SK-N-MC neuroblastoma cells stably expressing the human dopamine transporter were transfected with human α-synuclein and cell clones...
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