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An age-related accumulation in rats of 8-hydroxy-2 -deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and the effect of dietary restriction on the accumulation of 8-OHdG were examined. The 8-OHdG concentrations of nuclear DNA in organs of ad libitum fed rats were similar in young and middle age, but increased significantly in kidney at 24 months of age, in heart and liver at 27 months of...
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