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This review presents results from studies seeking evidence of the involvement of sensory structures in mediating signal interactions between the immune and nervous systems in the gastrointestinal tract. The data reported here provide evidence that the terminals of small intestine afferent fibers modulate the body’s reactions to administration of antigenic structures. The question of the involvement...
Lipoxygenase (LO) metabolites are generated in inflamed tissues. However, it is unclear whether the inhibition of the LO activity regulates the expression of c-Fos protein, a pain marker in the spinal cord. Here we used a carrageenan-induced inflammation model to examine the role of LO in the development of c-Fos expression. Intradermally injected carrageenan caused elevated number of cells exhibiting...
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