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The epidemic of type 2 diabetes (T2DM) is a public health problem that threatens to spiral out of control in the twenty-first century. Early intervention can greatly mitigate the serious socioeconomic impact of the disease, driven largely by disabling microvascular complications and cardiovascular disease. Obesity is at the core of the epidemic of T2DM, affecting 2/3 of adults and reaching alarming...
Summary The pathogenesis of nonalcoholic steatohepatitis (NASH) is not understood well. Therefore, it is necessary to examine genetic influences on NASH pathogenesis. Two functional polymorphisms were studied: the −493 G/T polymorphism in the promoter of microsomal triglyceride transfer protein (MTP) and the 1183 T/C polymorphism in the mitochondrial targeting sequence of manganese superoxide dismutase...
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