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Incubation of rat astrocytes or C6 glioma cells with norepinephrine (NE) suppresses bacterial endotoxin and cytokine-dependent induction of calcium-independent nitric oxide synthase [Feinstein et al., J. Neurochem., 60 (1993) 1945-1948]. We examined if NE also modified l-arginine uptake. Overnight incubation in 10 μM NE reduced the V max for uptake by 30-40%, but did not decrease...
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