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There is evidence that nitric oxide (NO) formation in adult cardiomyocytes stimulated with lipopolysaccharide (LPS) is not commensurate with iNOS levels. Tetrahydrobiopterin (BH 4 ) is a key factor in the stabilization and NO production by iNOS homodimer. Thus we hypothesized that BH 4 is a limiting factor for NO production in adult cardiomyocytes in response to LPS and cytokines (TNF-α,...
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