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Activation of brain glial cells with the bacterial endotoxin lipopolysaccharide (LPS), the HIV-1 coat protein gp120, or β-amyloid-derived peptides, stimulates the expression of several cytokines, including tumor necrosis factor-α (TNFα), interleukin-1 (IL-1) and IL-6, and nitric oxide (NO) which have been proposed as causes of neurodegeneration in the brain. In the present study, the neurotoxic effects...
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