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13.329 kilobases of the single copy human tyrosine hydroxylase (hTH) gene were isolated from a genomic library. The 5' flanking 11 kilobases fused to the reporter green fluorescent protein (GFP) drove high level expression in TH+ cells of the substantia nigra of embryonic and adult transgenic mice as determined by double label fluorescence microscopy. To provide a basis for future analysis of polymorphisms...
Developmental patterns of neuropeptide (NPY) and tyrosine hydroxylase (TH)-immunoreactivities (IR) were investigated using the method of indirect immunohistochemistry in the stellate and thoracic sympathetic ganglia of human neonates ranging in gestational age from 24 to 27 weeks (premature group) and from 38 to 41 weeks (mature group). In the paravertebral ganglia of premature neonates a small (up...
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