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The physiological and pharmacological roles of peroxisome proliferator-activated receptor-β (PPARβ-also referred to as PPARδ) are just beginning to emerge. It has recently become clear that PPARβ has a function in epithelial tissues, but controversy exists due to inconsistencies in the literature. There is strong evidence that ligand activation of PPARβ can induce terminal differentiation of keratinocytes,...
Human calmodulin-like protein (CLP) is a calcium-binding protein down-regulated in a cell culture model of mammary tumorigenesis as well as in a majority of breast cancers in vivo. CLP down-regulation may be a result of the poorly differentiated state of these cell lines and tumors, or CLP expression may be incompatible with the uncontrolled cell growth associated with tumorigenesis. To learn more...
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