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Tympanosclerosis is a middle ear disease located in submucous membrane. It leads to the tympanic membrane and ear ossicles fixation which results in severe conductive hearing impairment. The etiology of tympanosclerosis remains unclear. Cytokines play very important role in development of tympanosclerosis. The research aimed to assess gene expression level of pro inflammatory cytokine TNF-α in selected...
Bone destruction in chronic otitis media with cholesteatoma is a common phenomenon. Expanding growth of cholesteatoma in the middle ear causes ischemia of the mucosa and bones with granulation tissue production.was to assess the expression and distribution of the key regulators of bone destruction: osteoprotegerin (OPG), Receptor Activator for Nuclear Factor κ B Ligand (RANKL) and tumour necrosis...
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