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The goal of this research was to examine the effect of preconception paternal stress (PPS) on the subsequent neurodevelopment and behavior of male and female offspring. Prenatal (gestational) stress has been shown to alter brain morphology in the developing brain, and is presumed to be a factor in the development of some adult psychopathologies. Our hypothesis was that paternal stress in the preconception...
Schizophrenia is comprised of several symptom subtypes, including positive symptoms, negative symptoms, disorganization syndrome, and cognitive disturbances. Of these, evidence suggests that the positive symptoms are related to a dopaminergic hyperactivity within subcortical limbic regions, such as the nucleus accumbens. The accumbens itself receives overlapping inputs from several limbic areas, including...
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