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Hutchinson-Gilford progeria syndrome (HGPS) is a fatal segmental aging disorder affecting children. There is a paucity of prior data at the nucleotide level on DNA maintenance in HGPS. We have examined the specific nucleotide sequences and production of allelic transcripts from the locus GGTB2 encoding β(1-4) galactosyltransferase. Quantitative Northern blots of mRNA from HGPS and control fibroblasts...
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