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The chromosomal DNA of apoptotic cells and the nuclear DNA expelled from erythroid precursors is cleaved by DNase II in lysosomes after the cells or nuclei are engulfed by macrophages. DNase II−/− embryos suffer from lethal anemia due to IFN‐β produced in the macrophages carrying undigested DNA. Here, we show that Type I IFN induced a caspase‐dependent cell death in human epithelial cells that were...
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