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In the COMET study, carvedilol improved survival compared to metoprolol tartrate in 3029 patients with NYHA II–IV heart failure and EF <35%, followed for an average of 58 months.To evaluate whether the effect on overall mortality was specific for a particular mode of death. This may help to identify the mechanism of the observed difference.Of the 1112 total deaths, 972 were adjudicated as cardiovascular,...
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