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Aim: To evaluate the effects of antioxidant treatment of streptozotocin (STZ)‐diabetic rats with α‐lipoic acid (α‐LA) in neuronal and microglial activation at the spinal cord, an important relay station of nociceptive transmission. Because of the role of the potassium chloride co‐transporter 2 (KCC2) in neuronal activation at the spinal cord and the influence of microglia in KCC2 expression, we also...
Aim: Neuronal hyperactivity at the spinal cord during mechanical hyperalgesia induced by diabetes may result from a decrease in the local expression of the potassium chloride co‐transporter 2 (KCC2), which shifts the action of the neurotransmitter γ‐amminobutiric acid (GABA) from inhibitory to excitatory. In this study, we evaluated the effects of spinal microglia inhibition or brain‐derived neurotrophic...
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