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Objective
Inflammation plays an essential role in epilepsy. Studies indicate that cytokines and neurotrophic factors can act in neuroexcitability and epileptogenesis. We aimed to investigate the association between plasma inflammatory and neurotrophic markers, seizure frequency, and chronic epilepsy subtypes.
Methods
We studied 446 patients with epilepsy and 166 healthy controls. We classified...
Dravet syndrome (DS) is a refractory epileptic syndrome. Vaccination is the trigger of the first seizure in about 50% of cases. Fever remains a trigger of seizures during the course of the disease. We compared ex vivo cytokine responses to a combined aluminium‐adjuvanted vaccine of children with DS to sex‐ and age‐matched heathy children. Using ex vivo cytokine responses of peripheral‐blood mononuclear...
Astrocytes, the major glial cell type of the central nervous system (CNS), are known to play a major role in the regulation of the immune/inflammatory response in several human CNS diseases. In epilepsy‐associated pathologies, the presence of astrogliosis has stimulated extensive research focused on the role of reactive astrocytes in the pathophysiological processes that underlie the development of...
Epilepsy is common following various brain insults. We review experimental and clinical data supporting the involvement of a primary blood–brain barrier (BBB) injury in seizures and epileptogenesis. These data point to novel signaling cascades, which may offer new therapeutic targets for the prevention and treatment of epilepsy. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies...
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