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Aims
In patients with acute heart failure (AHF), the addition of hydrochlorothiazide (HCTZ) to furosemide improved diuretic response in the CLOROTIC trial. This work aimed to evaluate if these effects differ across the estimated glomerular filtration rate (eGFR) spectrum.
Methods and results
This post‐hoc analysis of the CLOROTIC trial analysed 230 patients with AHF and explored the influence of...
Furosemide is a diuretic and is used for the treatment of patients with heart failure (HF). It has been found that in some HF patients, the drug does not treat patients efficiently. This condition is named as furosemide resistance. In this study, it is aimed to investigate the relationship between UDP‐glucuronosyltransferase 1 (UGT1A1) and interleukine‐6 (IL‐6) variations with furosemide resistance...