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The effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks: the step-through passive avoidance paradigm and the object recognition test. Post-training injection of molsidomine (at 4 but not at 2mg/kg) significantly counteracted the performance deficits displayed by old rats in both the behavioral paradigms. These results support...
The ability of the nitric oxide (NO) synthase inhibitor, N G -nitro-l-arginine methyl ester (l-NAME), to modulate the attenuating effects of neurosteroids on the aging- and NMDA receptor antagonist dizocilpine-induced learning impairment, was tested in mice using two different behavioral models of long-term memory. The performance of aged mice (16 months old) in step-down type of passive-avoidance...
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