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Parkinson's disease (PD) is a common neurodegenerative condition, affecting 2–3% of those >65 years of age. Although it is classically defined as a movement disorder, patients also experience a range of non-motor symptoms, reflecting pathology that is more widespread than originally thought and affecting the peripheral and autonomic nervous system as well as the brainstem and cortex. Some non-motor...
Parkinson's disease was first described in 1817 by James Parkinson. It is one of the most common neurodegenerative disorders, affecting the nigrostriatal pathways involved in the control of movement. Since the introduction of L-DOPA as a therapy in the mid-1960s, clinical management of the symptoms has progressed, but, at present, it remains impossible to stop the disease progression or to restore...
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