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Mutations in the F-box only protein 7 (FBXO7) gene, located on chromosome 22q12-q13, have recently been identified as having distinct clinical features in patients with hereditary Parkinson's disease (PD). Pathologically, α-synuclein–positive inclusions have been identified using anti-FBXO7 antibody staining techniques. In the present study, we screened entire exons of FBXO7 from 271 patients (231...
The clinical and molecular of Alzheimer's disease, Parkinson's disease, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy and prion disease are reviewed. The hypothesis that these diseases share pathogenic pathways to cell death which involve either the tau or the α-synuclein proteins is propounded. The production and use of transgenic animal models...
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