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Hintergrund Clozapin wird als alternatives Antipsychotikum zur Kontrolle von Symptomen der Schizophrenie und zur Reduktion der Suizidrate bei Patienten eingesetzt, die nur unzureichend auf die Standardmedikation ansprechen. Der klinische Einsatz ist aufgrund schwerer kardialer Nebenwirkungen, einschließlich Kardiomyopathie und Myokarditis, begrenzt. Fallbericht Ein 31-jähriger Mann osteuropäischer...
Peripartum cardiomyopathy (PPCM) is a rare and potentially life-threatening disease that occurs toward the end of pregnancy or in the months following delivery in previously heart-healthy women. The incidence varies widely depending on geographical region and ethnic background, with an estimated number of 1 in 1000–1500 pregnancies in Germany. The course of the disease ranges from mild forms with...
Background Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the...
Es wird über den erfolgreichen Einsatz einer veno-venoarteriellen extrakorporalen Membranoxygenierung (vva-ECMO) bei einem 30-jährigen Patienten mit „acute respiratory distress syndrome“ (ARDS) und septischer Kardiomyopathie berichtet. Nach initialer Stabilisierung mithilfe der venoarteriellen (va-)ECMO wurde diese zur Verbesserung des pulmonalen und systemischen Sauerstoffangebots der oberen Körperhälfte...
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