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Die chronische Herzinsuffizienz ist eine fortschreitende Erkrankung, die bei vielen Patienten zum Tode führt. Veränderungen in der intrazellulären Signaltransduktion sowie in der Genexpression sind die vorwiegenden pathophysiologischen Mechanismen, die für die myokardiale Dysfunktion, den fortschreitenden Zellverlust und das daraus resultierende Remodeling ursächlich sind. Diese komplexen Veränderungen...
With the advancement in molecular techniques for characterizing genes and the use of animal models as tools to study heart failure, considerable progress has been made in improving our understanding of the regulation and function of genes associated with heart failure. Studies now indicate that autocrine/paracrine factors including neurohormones such as norepinephrine, angiotensin II, proinflammatory...
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