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Resistance towards chemotherapy, either primary or acquired, represents a major obstacle in clinical oncology. Three basic categories underlie most cases of chemotherapy failure: Inadequate pharmacokinetic properties of the drug, tumor cell intrinsic factors such as the expression of drug efflux pumps and tumor cell extrinsic conditions present in the tumor microenvironment, characterized by such...
This review provides a summary of the European Association for Cancer Research ‘Cancer Researcher Award’ lecture which was presented at the EACR21 meeting in Oslo, Norway, in July 2010. The review focuses on the importance of programmed cell death regulation in tumour development and cancer therapy. Eradication of damaged cells is a principal mechanism of protection against cancer and involves key...
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