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In dogs injected intravenously with 400mg/m 2 cyclophosphamide (CPA), the peripheral neutrophil count decreased to less than 1000cells/μL in 5–9 days. Treatment with purified recombinant canine granulocyte colony-stimulating factor (rcG-CSF), produced by brevibacillus expression system, at the nadir of the granulocyte count accelerated recovery from the CPA-induced neutropenia by 1–3 days...
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