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Purpose: The objective of this study was to quantify microglial and astrocytic cell responses after focal 125 I irradiation of normal brain and to determine the effects of an intravenous infusion of α-difluoromethylornithine (DFMO) on those responses.Methods and Materials: Adult beagle dogs were irradiated using high activity 125 I sources. Saline or DFMO (75 mg/kg/day)...
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