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The effects of nicotine on levels of Aβ 40 and Aβ 42 and nicotinic receptor binding sites were studied in brains from nonsmoking and smoking patients with Alzheimer's disease (AD) and aged-matched controls. The levels of soluble and insoluble Aβ 40 and Aβ 42 in frontal cortex and Aβ 40 in temporal cortex and hippocampus were significantly decreased in smoking AD patients compared to nonsmokers with...
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