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Corneal epithelial abrasion elicits an inflammatory response involving neutrophil (PMN) recruitment from the limbal vessels into the corneal stroma. These migrating PMNs make surface contact with collagen and stromal keratocytes. Using mice deficient in PMN integrin CD18, we previously showed that PMN contact with stromal keratocytes is CD18-dependent, while contact with collagen is CD18-independent...
Neutrophil migration into the corneal stroma following epithelial injury is an early event in the non-adaptive immune response. Little is known regarding the molecular and cellular mechanisms that regulate neutrophil migration within the injured cornea. In this article, evidence is presented supporting the idea that migrating neutrophils form integrin-dependent adhesive contacts not only with extracellular...
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