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Nisoxetine is a potent and selective inhibitor of noradrenaline uptake into noradrenergic neurones. [ 3 H]Nisoxetine binding to rat frontal cortical membranes was of high affinity. The binding data of both competition and saturation studies fitted a single site binding model. [ 3 H]Nisoxetine binding was potently inhibited by the selective noradrenaline uptake inhibitors desipramine...
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