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Using a three‐compartment physiologically based pharmacokinetic (PBPK) model and a tube model for hepatic extraction kinetics, equations for calculating blood drug levels (Cbs) and hepatic blood drug levels (Chbs, proportional to actual hepatic drug levels), were derived mathematically. Assuming the actual values for total body clearance (CLtot), oral bioavailability (F), and steady‐state distribution...
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