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Background Physical inactivity and unhealthy diet are modifiable behaviors that lead to several cancers. Biologically, these behaviors are linked to cancer through obesity-related insulin resistance, inflammation, and oxidative stress. Individual strategies to change physical activity and diet are often short lived with limited effects. Interventions are expected to be more successful when guided...
Cancer cachexia is a debilitating consequence of disease progression, characterised by the significant weight loss through the catabolism of both skeletal muscle and adipose tissue, leading to a reduced mobility and muscle function, fatigue, impaired quality of life and ultimately death occurring with 25–30 % total body weight loss. Degradation of proteins and decreased protein synthesis contributes...
Körperliche Aktivität verringert das Risiko, an Kolon-, Brust-, Endometrium-, Lungen- und Pankreaskrebs zu erkranken. Die Evidenz für einen kausalen Zusammenhang zwischen körperlicher Aktivität und Krebs wird durch den Nachweis der diesem zugrunde liegenden molekularen Wirkmechanismen in experimentellen Studien erheblich gestärkt. Randomisierte Interventionsstudien belegen inzwischen Effekte von körperlicher...
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