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This article summarizes the work done by our laboratory and by our collaborators on the biological role of chemokines and their receptors. Using both gain-of-function and loss of function genetic approaches, we have demonstrated that chemokines are important for the homeostatic distribution of leukocytes in tissues and for their mobilization from the bone marrow. We have also shown that chemokines...
Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood disorders, Alzheimer’s disease, diabetes, and cancer. Involvement in such disparate...
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