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A concise total synthesis of spirastrellolide A methyl ester (1 a, R1=Me) as the parent compound of a series of highly cytotoxic marine macrolides is disclosed, which exploits and expands the flexibility of a synthesis plan previously developed by our group en route to the sister compound spirastrellolide F methyl ester (6 a, R1=Me). Key to success was the masking of the signature Δ15,16‐bond of 1 a...
Two worlds, one molecule…︁ In their Full Paper on page 3596 ff. A. Fürstner et al. report a total synthesis of spirastrellolide A methyl ester, a complex macrolide isolated from a Caribbean sponge collected off Dominica. Several methodological spin‐offs as well as preliminary structure–activity relationship data are also disclosed. Artwork: R. Homann for MPI für Kohlenforschung; photographs: Copyright:...
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