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A novel polyketide Kendomycin with a unique quinone methide ansa structure and an impressive biological activity profile is obtained through two concise and efficient syntheses of the compound, one of which features a novel photo‐Fries rearrangement to close a highly strained all carbon macrocycle. For details see the Full Paper by J. Mulzer et al. on page 507 ff.
Two convergent total syntheses of the ansa‐polyketide (−)‐kendomycin (1) are described. The syntheses benefit from the use of readily available and cheap starting materials. Highly complex diastereoselective Claisen–Ireland rearrangements were used to introduce the (E)‐double bond and the C16‐Me group. The ring closure of the strained ansa macrocycle was achieved by ring‐closing metathesis and a highly...
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