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Metastasis is a major cause of poor prognosis and recurrence in cancer patients. We have previously reported that cancer metastasis may be prevented by proton beam irradiation via the induction of tissue inhibitor of matrix metalloproteases-1 and -2, known as anti-metastatic factors, and the suppression of aromatase in MCF-7 human breast cancer cells. However, the prior report did not show the effect...
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