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The synthesis of small organic molecules with a difluoromethylated stereocenter is particularly attractive in drug discovery. Herein, we have developed an efficient method for the direct generation of difluoromethylated stereocenters through Ni0‐catalyzed regio‐ and enantioselective hydrosilylation of gem‐difluoroalkenes. The reaction also represents the enantioselective construction of carbon(sp3...
The synthesis of small organic molecules with a difluoromethylated stereocenter is particularly attractive in drug discovery. Herein, we have developed an efficient method for the direct generation of difluoromethylated stereocenters through Ni0‐catalyzed regio‐ and enantioselective hydrosilylation of gem‐difluoroalkenes. The reaction also represents the enantioselective construction of carbon(sp3...