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Aims/hypothesis One in four children with Type 1 diabetes in a population-based family study has an affected grandparent. We set out to study the clinical and immune features of diabetes in the grandparents' generation, and to examine sharing of HLA class II susceptibility haplotypes between grandparent and grandchild. Methods Of 5855 grandparents in the Bart's-Oxford family study, 428 (7.3%) were...
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