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Soluble N-ethylmaleimide-sensitive fusion protein attachment proteins (SNAP) proteins function in Ca 2+ -regulated exocytosis. Recent work (Schiavo et al. (1996) Nature 378, 733-736) based on in vitro protein interactions has raised the possibility that α- and β-SNAPs have distinct roles in exocytosis. We have examined this possibility by comparing the activities of recombinant α- and...
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